منابع مشابه
a-Synuclein oligomers distinctively permeabilize complex model membranes
doi:10.1111/febs.12824 a-Synuclein oligomers are increasingly considered to be responsible for the death of dopaminergic neurons in Parkinson’s disease. The toxicity mechanism of a-synuclein oligomers likely involves membrane permeabilization. Even though it is well established that a-synuclein oligomers bind and permeabilize vesicles composed of negatively-charged lipids, little attention has ...
متن کاملProcess of inducing pores in membranes by melittin.
Melittin is a prototype of the ubiquitous antimicrobial peptides that induce pores in membranes. It is commonly used as a molecular device for membrane permeabilization. Even at concentrations in the nanomolar range, melittin can induce transient pores that allow transmembrane conduction of atomic ions but not leakage of glucose or larger molecules. At micromolar concentrations, melittin induce...
متن کاملBax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis.
Bax promotes cell death by permeabilizing mitochondrial outer membranes by an unresolved mechanism. However, in cells lacking the gene c-myc, membrane permeabilization by Bax is blocked by changes in the mitochondria that prevent Bax oligomerization. Drug-treated c-myc null cells and cells expressing Myc were used to map the topology of Bax in membranes prior to and after mitochondrial permeabi...
متن کاملBIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes.
BIM and tBID are two BCL-2 homology 3 (BH3)-only proteins with a particularly strong capacity to trigger BAX-driven mitochondrial outer membrane permeabilization, a crucial event in mammalian apoptosis. However, the means whereby BIM and tBID fulfill this task is controversial. Here, we used a reconstituted liposomal system bearing physiological relevance to explore systematically how the BAX-p...
متن کاملBiomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes.
Rational design and engineering of membrane-active peptides remains a largely unsatisfied goal. We have hypothesized that this is due, in part, to the fact that some membrane activities, such as permeabilization, are not dependent on specific amino acid sequences or specific three-dimensional peptide structures. Instead they depend on interfacial activity: the ability of a molecule to partition...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.3738